The first symptoms are ache, pus and swollen condition.But the bone hides the puffiness because of its hardness. Suppuration can cause strong fire appearing suddenly .Sometimes vomiting is seen. Because the aorta dont connect the venous, infection affects around the knees and elbows of the tall bones(end-arters). The bactery is ended there.The pus causes the pressure on blood preventing the flow of the blood because of the inflammation.So some parts of the bone lose function.The pus can be emtied by opening the skin.50% of the people which were exposed to the sickness have died because of the sickness before the invention of the antibiotics because of the spreading of the cancer to the other organs like lungs. The only danger today is the chronic bone marrow inflammation.The inflammation goes on the swelling and pus,the bone weaks and infection has the acut form. Tuberclosis bacteries can cause inflammation in the bone. They spread directly to the vertebra bones. This type inflammation move slowly but abrade the bone .The discs remain only.The bones growing cannot carry the body and cause hunchbacking.This crookedness is called as kifoz.